RT Journal Article
SR Electronic
T1 Multiple timescales account for adaptive responses across sensory cortices
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 700062
DO 10.1101/700062
A1 Kenneth W. Latimer
A1 Dylan Barbera
A1 Michael Sokoletsky
A1 Bshara Awwad
A1 Yonaton Katz
A1 Israel Nelken
A1 Ilan Lampl
A1 Adrienne Fairhall
A1 Nicholas J. Priebe
YR 2019
UL http://biorxiv.org/content/early/2019/07/14/700062.abstract
AB Sensory systems encounter remarkably diverse stimuli in the external environment. Natural stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of adaptation, ubiquitous feature of sensory systems, allow for the accommodation of this range of scales. Are there common rules of adaptation across different sensory modalities? We measured the membrane potential responses of individual neurons in the visual, somatosensory and auditory cortices to discrete, punctate stimuli delivered at a wide range of fixed and nonfixed frequencies. We find that the adaptive profile of the response is largely preserved across these three areas, exhibiting attenuation and responses to the cessation of stimulation which are signatures of response to changes in stimulus statistics. We demonstrate that these adaptive responses can emerge from a simple model based on the integration of fixed filters operating over multiple time scales.