TY - JOUR T1 - Collaborative Cross Mouse Populations as a Resource for the Study of Epilepsy JF - bioRxiv DO - 10.1101/690917 SP - 690917 AU - Bin Gu AU - John R. Shorter AU - Lucy H. Williams AU - Timothy A. Bell AU - Pablo Hock AU - Katherine A. Dalton AU - Yiyun Pan AU - Darla R. Miller AU - Ginger D. Shaw AU - Brian C. Cooley AU - Benjamin D. Philpot AU - Fernando Pardo-Manuel de Villena Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/07/15/690917.abstract N2 - Epilepsy is a neurological disorder with complex etiologies and genetic architecture. Animal models have a critical role in understanding the pathophysiology of epilepsy. Here we studied epilepsy utilizing a genetic reference population of Collaborative Cross (CC) mice with publicly available whole genome sequences. We measured multiple epilepsy traits in 35 CC strains, and we identified novel animal models that exhibit extreme outcomes in seizure susceptibility, seizure propagation, epileptogenesis, and sudden unexpected death in epilepsy. We performed QTL mapping in an F2 population and identified seven novel and one previously identified loci associated with seizure sensitivity. We combined whole genome sequence and hippocampal gene expression to pinpoint biologically plausible candidate genes and candidate variants associated with seizure sensitivity. These resources provide a powerful toolbox for studying complex features of seizures and for identifying genes associated with particular seizure outcomes, and hence will facilitate the development of new therapeutic targets for epilepsy. ER -