PT - JOURNAL ARTICLE AU - Terwilliger, Thomas C. AU - Adams, Paul D. AU - Afonine, Pavel V. AU - Sobolev, Oleg V. TI - A fully automatic method yielding initial models from high-resolution electron cryo-microscopy maps AID - 10.1101/267138 DP - 2018 Jan 01 TA - bioRxiv PG - 267138 4099 - http://biorxiv.org/content/early/2018/02/16/267138.short 4100 - http://biorxiv.org/content/early/2018/02/16/267138.full AB - A fully automated procedure for optimization and interpretation of reconstructions from cryo-EM is developed and applied to 476 datasets with resolution of 4.5 Å or better, including reconstructions of 47 ribosomes and 32 other protein-RNA complexes. The median fraction of residues in the deposited structures reproduced automatically was 71% for reconstructions determined at resolutions of 3 Å or better and 47% for those at lower resolution.