RT Journal Article
SR Electronic
T1 Structural control energy of resting-state functional brain states reveals inefficient brain dynamics in psychosis vulnerability
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 703561
DO 10.1101/703561
A1 Daniela Zöller
A1 Corrado Sandini
A1 Marie Schaer
A1 Stephan Eliez
A1 Danielle S. Bassett
A1 Dimitri Van De Ville
YR 2019
UL http://biorxiv.org/content/early/2019/07/16/703561.abstract
AB How the brain’s white-matter anatomy constrains brain activity is an open question that might give insights into the mechanisms that underlie mental disorders such as schizophrenia. Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder with an extremely high risk for psychosis providing a test case to study developmental aspects of schizophrenia. In this study, we used principles from network control theory to probe the implications of aberrant structural connectivity for the brain’s functional dynamics in 22q11DS. We retrieved brain states from resting-state functional magnetic resonance images of 78 patients with 22q11DS and 85 healthy controls, and we compared them in terms of persistence control energy based on individual structural connectivity. Control energy was altered in a broad pattern of brain states including both energetically more demanding and less demanding brain states in 22q11DS. Further, we discovered that the brain minimizes energy by spending less time in energetically demanding brain states. In patients with 22q11DS, this behavior was less pronounced, suggesting a dynamic inefficiency of brain function in the disease. In summary, our results provide initial insights into the dynamic implications of altered structural connectivity in 22q11DS, which might improve our understanding of the mechanisms underlying the disease.