RT Journal Article
SR Electronic
T1 Cell type specific control of basolateral amygdala plasticity via entorhinal cortex-driven feedforward inhibition
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 348524
DO 10.1101/348524
A1 E. Mae Guthman
A1 Joshua D. Garcia
A1 Ming Ma
A1 Philip Chu
A1 Serapio M. Baca
A1 Katharine R. Smith
A1 Diego Restrepo
A1 Molly M. Huntsman
YR 2019
UL http://biorxiv.org/content/early/2019/07/16/348524.abstract
AB The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literature implicating parvalbumin expressing (PV+) INs in FFI in cortex and hippocampus, prior anatomical experiments in BLA implicate somatostatin expressing (Sst+) INs. The lateral entorhinal cortex (LEC), a brain region carrying olfactory information, projects to BLA where it drives FFI. In the present study, we asked whether LEC input mediates plasticity in BLA and explored the role of interneurons in this circuit. We combined patch clamp electrophysiology, chemogenetics, unsupervised cluster analysis, and predictive modeling and found that a previously unreported subpopulation of fast-spiking Sst+ INs mediate LEC→BLA FFI and gate plasticity. Our study raises the question whether this circuit is involved in plasticity in olfactory learning.