PT  - JOURNAL ARTICLE
AU  - Masaaki Sato
AU  - Kotaro Mizuta
AU  - Tanvir Islam
AU  - Masako Kawano
AU  - Takashi Takekawa
AU  - Daniel Gomez-Dominguez
AU  - Karam Kim
AU  - Hiroshi Yamakawa
AU  - Masamichi Ohkura
AU  - Tomoki Fukai
AU  - Junichi Nakai
AU  - Yasunori Hayashi
TI  - Dynamic embedding of salience coding in hippocampal spatial maps
AID  - 10.1101/266767
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 266767
4099  - http://biorxiv.org/content/early/2018/02/18/266767.short
4100  - http://biorxiv.org/content/early/2018/02/18/266767.full
AB  - Hippocampal CA1 neurons participate in dynamic ensemble codes for space and memory. Prominent features of the environment are represented by an increased density of place cells, but cellular principles governing the formation and plasticity of such disproportionate maps are unknown. We thus imaged experience-dependent long-term changes in spatial representations at the cellular level in the CA1 deep sublayer in mice learning to navigate in a virtual-reality environment. The maps were highly dynamic but gradually stabilized as over-representations for motivational (reward) and environmental (landmark) salience emerged in different time courses by selective consolidation of relevant spatial representations. Relocation of the reward extensively reorganized pre-formed maps by a mechanism involving rapid recruitment of cells from the previous location followed by their re-stabilization, indicating that a subset of neurons encode reward-related information. The distinct properties of these CA1 cells may provide a substrate by which salient experience forms lasting and adaptable memory traces.