RT Journal Article
SR Electronic
T1 Whole-genome sequencing of parvoviruses from wild and domestic animals in Brazil provides new insights into parvovirus distribution and diversity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 268219
DO 10.1101/268219
A1 William Marciel de Souza
A1 Tristan Philip Wesley Dennis
A1 Marcílio Jorge Fumagalli
A1 Jansen de Araujo
A1 Gilberto Sabino-Santos, Jr
A1 Felipe Gonçalves Motta Maia
A1 Gustavo Olszanski Acrani
A1 Adriano de Oliveira Torres Carrasco
A1 Marilia Farignoli Romeiro
A1 Sejal Modha
A1 Luiz Carlos Vieira
A1 Tatiana Lopes Ometto
A1 Luzia Helena Queiroz
A1 Edison Luiz Durigon
A1 Márcio Roberto Teixeira Nunes
A1 Luiz Tadeu Moraes Figueiredo
A1 Robert James Gifford
YR 2018
UL http://biorxiv.org/content/early/2018/02/20/268219.abstract
AB Parvoviruses (family Parvoviridae) are small, single-stranded DNA viruses. Many parvoviral pathogens of medical, veterinary and ecological importance have been identified. In this study, we used high-throughput sequencing (HTS) to investigate the diversity of parvoviruses infecting wild and domestic animals in Brazil. We identified 21 parvovirus sequences (including twelve nearly complete genomes and nine partial genomes) in samples derived from rodents, bats, opossums, birds and cattle in Pernambuco, São Paulo, Paraná and Rio Grande do Sul states. These sequences were investigated using phylogenetic and distance-based approaches, and were thereby classified into eight parvovirus species (six of which have not been described previously), representing six distinct genera in the subfamily Parvovirinae. Our findings extend the known biogeographic range of previously characterized parvovirus species, and the known host range of three parvovirus genera (Dependovirus, Aveparvovirus, and Tetraparvovirus). Moreover, our investigation provides a window into the ecological dynamics of parvovirus infections in vertebrates, revealing that many parvovirus genera contain well-defined sub-lineages that circulate widely throughout the world within particular taxonomic groups of hosts.