RT Journal Article SR Electronic T1 PyIOmica: Longitudinal Omics Analysis and Classification JF bioRxiv FD Cold Spring Harbor Laboratory SP 708941 DO 10.1101/708941 A1 Sergii Domanskyi A1 Carlo Piermarocchi A1 George I. Mias YR 2019 UL http://biorxiv.org/content/early/2019/07/19/708941.abstract AB Summary PyIOmica is an open-source Python package focusing on integrating longitudinal multiple omics datasets, characterizing, and classifying temporal trends. The package includes multiple bioinformatics tools including data normalization, annotation, classification, visualization, and enrichment analysis for gene ontology terms and pathways. Additionally, the package includes an implementation of visibility graphs to visualize time series as networks.Availability and implementation PyIOmica is implemented as a Python package (pyiomica), available for download and installation through the Python Package Index (PyPI) (https://pypi.python.org/pypi/pyiomica), and can be deployed using the Python import function following installation. PyIOmica has been tested on Mac OS X, Unix/Linux and Microsoft Windows. The application is distributed under an MIT license. Source code for each release is also available for download on Zenodo (https://doi.org/10.5281/zenodo.3342612).Contact gmias{at}msu.edu