PT  - JOURNAL ARTICLE
AU  - Gizem Karsli Uzunbas
AU  - Faraz Ahmed
AU  - Morgan A. Sammons
TI  - Cell type-dependent control of p53 transcription and enhancer activity by p63
AID  - 10.1101/268649
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 268649
4099  - http://biorxiv.org/content/early/2018/02/21/268649.short
4100  - http://biorxiv.org/content/early/2018/02/21/268649.full
AB  - Transcriptional activation by p53 provides powerful, organism-wide tumor suppression. In this work, we demonstrate that the p53-induced transcriptome is dependent on pre-establishment of cell type-dependent cis-regulatory networks. The epithelial-specific p53 transcriptome is strongly dependent on the p53 family member p63, which acts as a pioneer factor for epithelial-specific enhancers. These results suggest a broad mechanism for regulating the p53-dependent cellular response to stress through differential regulation of cis-regulatory elements and identify p63 as a direct and critical regulator of enhancer activity in epithelial cell types.