PT  - JOURNAL ARTICLE
AU  - Aleida Rodríguez-Castañenda
AU  - Katia Leticia Martínez-Gonzáles
AU  - Rosalinda Sánchez-Arenas
AU  - Sergio Sánchez-García
AU  - Israel Grijalva
AU  - Lourdes Basurto
AU  - Juan Cuadros-Moreno
AU  - Eliseo Ramírez-Garcia
AU  - Paola Garcia-delaTorre
TI  - Oxidative stress in an aged population with diabetes mellitus and/or hypertension
AID  - 10.1101/269993
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 269993
4099  - http://biorxiv.org/content/early/2018/02/22/269993.short
4100  - http://biorxiv.org/content/early/2018/02/22/269993.full
AB  - Mexico City has the highest aging rate in the country, as well as a high prevalence of diabetes mellitus (DM) and hypertension (HAS). All three on their own, are known to increase oxidative stress (OE). With this study, we have described changes in OE in 18 patients without DM or HAS, 12 with DM, 23 with HAS, and 18 with DM and HAS. The EO was measured by the quantification of reactive oxygen species (ROS), and by determination of lipid peroxidation. HAS patients showed increased ROS levels as did men with HAS compared with the respective DM and HAS groups. Also, women of the control group showed higher levels of ROS compared with men. HAS in an aged population turned out to be the most influential factor for oxidative stress increase while DM had no effect whatsoever.