RT Journal Article
SR Electronic
T1 Lung Cancer Explorer (LCE): an open web portal to explore gene expression and clinical associations in lung cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 271056
DO 10.1101/271056
A1 Ling Cai
A1 ShinYi Lin
A1 Yunyun Zhou
A1 Lin Yang
A1 Bo Ci
A1 Qinbo Zhou
A1 Danni Luo
A1 Bo Yao
A1 Hao Tang
A1 Jeffrey Allen
A1 Kenneth Huffman
A1 Adi Gazdar
A1 John Heymach
A1 Ignacio Wistuba
A1 Guanghua Xiao
A1 John Minna
A1 Yang Xie
YR 2018
UL http://biorxiv.org/content/early/2018/02/24/271056.abstract
AB We constructed a lung cancer-specific database housing expression data and clinical data from over 6,700 patients in 56 studies. Expression data from 23 “whole-genome” based platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource – the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Users can perform meta-analyses on LCE to gain a quick overview of the results on tumor vs normal differential gene expression and expression-survival association. Individual dataset-based survival analysis, comparative analysis, and correlation analysis are also provided with flexible options to allow for customized analyses from the user.