TY - JOUR T1 - Hypoarousal non-stationary ADHD biomarker based on echo-state networks JF - bioRxiv DO - 10.1101/271858 SP - 271858 AU - D. Ibanez-Soria AU - A. Soria-Frisch AU - J. Garcia-Ojalvo AU - Jacobo Picardo AU - Gloria GarcĂ­a-Banda AU - Mateu Servera AU - Giulio Ruffini Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/02/26/271858.abstract N2 - Attention-Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity and impulsivity. It is one of the most commonly diagnosed neurodevelopmental and psychiatric disorders of childhood and therefore presents a very high prevalence rate. However the high rate of ADHD misdiagnosis makes the discovery of neurophysiological ADHD biomarkers an important clinical challenge. This study proposes a novel non-stationary ADHD biomarker based on Echo State Networks to quantify EEG dynamical changes between low attention/arousal states (resting with eyes closed, or EC) and normal attention/arousal states (resting with eyes open, or EO). Traditionally, EEG biomarkers have revealed an increase in stationary power in the theta band along with a decrease in beta, with these frequencies largely accepted to be altered in the ADHD population. We successfully verify the hypothesis that measured differences between these two conditions are altered in the ADHD population. Statistically significant differences between a group of ADHD subjects and an aged-matched control population were obtained in theta and beta rhythms. Our network discriminates between EO/EC EEG regimes in the ADHDs better than in controls, suggesting that differences in EEG patterns between low and normal arousal/attention states are larger in the ADHD population. ER -