@article {Runge271247, author = {Jan-Niklas Runge and Anna K. Lindholm}, title = {The t haplotype, a selfish genetic element, manipulates migration propensity in free-living wild house mice Mus musculus domesticus}, elocation-id = {271247}, year = {2018}, doi = {10.1101/271247}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Life is built on cooperation between genes, which makes it vulnerable to parasitism. However, selfish genetic elements that exploit this cooperation can achieve large fitness gains by increasing their transmission unfairly relative to the rest of the genome. This leads to counter-adaptations that generate unique selection pressures on the selfish genetic element. This arms race is similar to host-parasite co-evolution. Some multi-host parasites alter the host{\textquoteright}s behaviour to increase the chance of transmission to the next host. Here we ask if, similarly to these parasites, a selfish genetic element in house mice, the t haplotype, also manipulates host behaviour, specifically the host{\textquoteright}s migration propensity. Variants of the t that manipulate migration propensity could increase in fitness in a meta-population. We show that juvenile mice carrying the t haplotype were more likely to emigrate from and were more often found as migrants within a long-term free-living house mouse population. This result may have applied relevance as the t has been proposed as a basis for artificial gene drive systems for use in population control.}, URL = {https://www.biorxiv.org/content/early/2018/02/27/271247}, eprint = {https://www.biorxiv.org/content/early/2018/02/27/271247.full.pdf}, journal = {bioRxiv} }