RT Journal Article
SR Electronic
T1 Age-related Gene Expression Signatures (AGES) in rats demonstrate early, late, and linear transcriptional changes from multiple tissues
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 717835
DO 10.1101/717835
A1 Tea Shavlakadze
A1 Melody Morris
A1 Jian Fang
A1 Sharon X. Wang
A1 Weihua Zhou
A1 Herman W. Tse
A1 Ricardo Mondragon-Gonzalez
A1 Guglielmo Roma
A1 David J. Glass
YR 2019
UL http://biorxiv.org/content/early/2019/07/28/717835.abstract
AB In order to understand changes in gene expression that occur as a result of age, which might create a permissive or causal environment for age-related diseases, we produced a multi-timepoint Age-related Gene Expression Signature (AGES) from liver, kidney, skeletal muscle and hippocampus of rats, comparing 6, 9, 12, 18, 21, 24 and 27-month old animals. We focused on genes that changed in one direction throughout the lifespan of the animal, either early in life (early logistic changes); at mid-age (mid-logistic); late in life (late-logistic); or linearly, throughout the lifespan. The pathways perturbed as a result of chronological age demonstrate organ-specific and more global effects of aging, and point to mechanisms that might be counter-regulated pharmacologically in order to treat age-associated diseases. A small number of genes were regulated by aging in the same manner in every tissue, suggesting they may be more universal markers of aging.