PT  - JOURNAL ARTICLE
AU  - Zhixing Cao
AU  - Tatiana Filatova
AU  - Diego A. Oyarzún
AU  - Ramon Grima
TI  - Multi-scale bursting in stochastic gene expression
AID  - 10.1101/717199
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 717199
4099  - http://biorxiv.org/content/early/2019/07/28/717199.short
4100  - http://biorxiv.org/content/early/2019/07/28/717199.full
AB  - Transcriptional bursting is a major source of noise in gene expression. Motivated by recent experiments, we study a model including slow burst initiation and termination, and fast RNA polymerase recruitment and pause release. We show that the time-dependent distribution of mRNA numbers is accurately approximated by a telegraph model with a Michaelis-Menten like dependence of the effective transcription rate on polymerase abundance. We also show that gene dosage compensation, a common feature of mammalian gene expression, is an emergent property of our stochastic model.