PT - JOURNAL ARTICLE AU - Frieboes, Hermann B. TI - Overview: Modeling Heterogeneous Tumor Tissue as a Multiphase Material AID - 10.1101/031534 DP - 2015 Jan 01 TA - bioRxiv PG - 031534 4099 - http://biorxiv.org/content/early/2015/11/12/031534.short 4100 - http://biorxiv.org/content/early/2015/11/12/031534.full AB - Tumors are typically heterogeneous tissues comprised of multiple cell species in addition to extra-cellular matrix (ECM) and water fluid. It is difficult to model these components at the tissue (10−3–10−2m) scale, where individual cells cannot be represented without prohibitive computational burden. Assuming that same-kind components tend to cluster together, a multiphase approach can be applied to represent heterogeneous tumor tissue at this larger physical scale. This method enables simulating mixture of elements within tissues, e.g., geno-/phenotypic heterogeneity underlying mutation- or microenvironment-driven tumor progression. Further, by not explicitly tracking interfaces, this methodology facilitates realistic modeling of tissue in 3-D.