PT  - JOURNAL ARTICLE
AU  - George Dimitriadis
AU  - Joana P. Neto
AU  - Arno Aarts
AU  - Andrei Alexandru
AU  - Marco Ballini
AU  - Francesco Battaglia
AU  - Lorenza Calcaterra
AU  - Francois David
AU  - Richárd Fiáth
AU  - João Frazão
AU  - Jesse Geerts
AU  - Luc J. Gentet
AU  - Nick Van Helleputte
AU  - Tobias Holzhammer
AU  - Chris van Hoof
AU  - Domonkos Horváth
AU  - Gonçalo Lopes
AU  - Eric Maris
AU  - Andre Marques-Smith
AU  - Gergely Márton
AU  - Domokos Meszéna
AU  - Srinjoy Mitra
AU  - Silke Musa
AU  - Hercules Neves
AU  - Joana Nogueira
AU  - Guy A. Orban
AU  - Frederick Pothof
AU  - Jan Putzeys
AU  - Bogdan Raducanu
AU  - Patrick Ruther
AU  - Tim Schroeder
AU  - Wolf Singer
AU  - Paul Tiesinga
AU  - Istvan Ulbert
AU  - Shiwei Wang
AU  - Marleen Welkenhuysen
AU  - Adam R. Kampff
TI  - Why not record from <em>every</em> channel with a CMOS scanning probe?
AID  - 10.1101/275818
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 275818
4099  - http://biorxiv.org/content/early/2018/03/03/275818.short
4100  - http://biorxiv.org/content/early/2018/03/03/275818.full
AB  - Neural recording devices normally require one output connection for each electrode. This constrains the number of electrodes that can be accommodated by the thin shafts of implantable probes.Sharing a single output connection between multiple electrodes relaxes this constraint and permits designs of ultra-high density neural probes.Here we report the design and in vivo validation of such a device, a complementary metal-oxide-semiconductor (CMOS) scanning probe with 1344 electrodes and 12 reference electrodes along an 8.1 mm x 100 μm x 50 μm shaft; the outcome of the European research project NeuroSeeker. This technology presented new challenges for data management and visualization, and we also report new methods addressing these challenges developed within NeuroSeeker.Scanning CMOS technology allows the fabrication of much smaller, denser electrode arrays. To help design electrode configurations for future probes, several recordings from many different brain regions were made with an ultra-dense passive probe fabricated using CMOS process. All datasets are available online.