RT Journal Article
SR Electronic
T1 Spatial organization of the somatosensory cortex revealed by cyclic smFISH
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 276097
DO 10.1101/276097
A1 Simone Codeluppi
A1 Lars E. Borm
A1 Amit Zeisel
A1 Gioele La Manno
A1 Josina A. van Lunteren
A1 Camilla I. Svensson
A1 Sten Linnarsson
YR 2018
UL http://biorxiv.org/content/early/2018/03/04/276097.abstract
AB The global efforts towards the creation of a molecular census of the brain using single-cell transcriptomics is generating a large catalog of molecularly defined cell types lacking spatial information. Thus, new methods are needed to map a large number of cell-specific markers simultaneously on large tissue areas. Here, we developed a cyclic single molecule fluorescence in situ hybridization methodology and defined the cellular organization of the somatosensory cortex using markers identified by single-cell transcriptomics.