RT Journal Article
SR Electronic
T1 Lifestyle-intervention-induced reduction of abdominal fat is reflected by a decreased circulating glycerol level and an increased HDL diameter
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 718023
DO 10.1101/718023
A1 Marian Beekman
A1 Bianca A.M. Schutte
A1 Erik B. van den Akker
A1 Raymond Noordam
A1 Petra Dibbets-Schneider
A1 Lioe-Fee de Geus-Oei
A1 Joris Deelen
A1 Ondine van de Rest
A1 Diana van Heemst
A1 Edith J.M. Feskens
A1 P. Eline Slagboom
YR 2019
UL http://biorxiv.org/content/early/2019/07/30/718023.abstract
AB Abdominal obesity is one of the main modifiable risk factors of age-related cardiometabolic disease. Cardiometabolic disease risk and its associated high abdominal fat mass, high cholesterol and glucose concentrations can be reduced by a healthier lifestyle. Hence, our aim is to understand the relation between lifestyle-induced changes in body composition, and specifically abdominal fat, and accompanying changes in circulating metabolic biomarkers.Methods and results We used the data from the Growing Old Together (GOTO) study, in which 164 older adults (mean age 63 years, BMI 23-35 kg/m2) changed their lifestyle during 13 weeks by 12.5% caloric restriction plus 12.5% increase in energy expenditure. We show that levels of circulating metabolic biomarkers, even after adjustment for body mass index, specifically associate with abdominal fat mass. Next, we show that the applied lifestyle intervention mainly reduces abdominal fat mass (−2.6%, SD=3.0) and that this reduction, when adjusted for general weight loss, is highly associated with decreased circulating glycerol concentrations and increased HDL diameter.Conclusions The lifestyle-induced reduction of abdominal fat mass is particularly associated, independent of body mass index or general weight loss, with associated with decreased circulating glycerol concentrations and increased HDL diameter.1H-NMRProton Nuclear Magnetic ResonanceApoBApolipoprotein BBCAABranched-Chain Amino AcidBMIBody Mass IndexCVDCardiovascular diseaseDXADual X-ray AbsorptiometryGlolGlycerolGOTOGrowing Old TOgether (Lifestyle intervention study)HDLHigh Density LipoproteinLDLLow Density LipoproteinMUFAMonounsaturated Fatty AcidSDStandard deviationVLDLVery Low Density Lipoprotein