TY - JOUR T1 - A preliminary study of the cytotoxicity of the protein extract of <em>Chrysobalanus icaco</em> L. and <em>Eugenia astringens</em> Cambess., commercialized in markets JF - bioRxiv DO - 10.1101/720052 SP - 720052 AU - Thaís A. Pedrete AU - Julianderson O.S. Carmo AU - Emiliano O. Barreto AU - Josino C. Moreira Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/07/31/720052.abstract N2 - The use of plants and their products for medical treatment is very common procedure in Brazil, especially for treatment of diabetes. In fact, several plants can demonstrate hypoglycemic effects in vitro assays. However, the use for human treatment requires the knowledge of their toxicological properties. The aim of this study was to evaluate the effect of protein extracts of Chrysobalanus icaco collected from natural habitats and of Eugenia astringens acquired from the market of Rio de Janeiro on the viability and migration of fibroblasts. E. astringens has a similar morphology as C. icaco and it is sold as Chrysobalanus in a popular market in Rio de Janeiro. Being a different plant, E. astringens expresses different proteins, and its protein extract has proved to possess higher toxic properties than C. icaco does. Cytotoxicity assays indicated that, as the protein extract concentration increases, fibroblast viability decreases. Only the E. astringens extract displayed cytotoxicity at all concentrations, in addition to reduced fibroblast migration. The results obtained in this study demonstrates that it’s necessary integrative policies for rational use of medicinal plants and their commercialization, since the current use of medicinal plants may be inadequate and it is of great importance for Public Health.MADMercadão de Madureira;PGPraia Grande;RMARestinga de Massambaba;ALMarechal Deodoro;MTT3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. ER -