RT Journal Article
SR Electronic
T1 On the distribution of tract lengths during adaptive introgression
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 724815
DO 10.1101/724815
A1 Vladimir Shchur
A1 Jesper Svedberg
A1 Paloma Medina
A1 Russ Corbett-Detig
A1 RASMUS Nielsen
YR 2019
UL http://biorxiv.org/content/early/2019/08/05/724815.abstract
AB Admixture is increasingly being recognized as an important factor in evolutionary genetics. The distribution of genomic admixture tracts, and the resulting effects on admixture linkage disequilibrium, can be used to date the timing of admixture between species or populations. However, the theory used for such prediction assumes selective neutrality despite the fact that many famous examples of admixture involve natural selection acting for or against admixture. In this paper, we investigate the effects of positive selection on the distribution of tract lengths. We develop a theoretical framework that relies on approximating the trajectory of the selected allele using a logistic function. By numerically calculating the expected allele trajectory, we also show that the approach can be extended to cases where the logistic approximation is poor due to the effects of genetic drift. Using simulations, we show that the model is highly accurate under most scenarios. We use the model to show that positive selection on average will tend to increase the admixture tract length. However, perhaps counter-intuitively, conditional on the allele frequency at the time of sampling, positive selection will actually produce shorter expected tract lengths. We discuss the consequences of our results in interpreting the timing of the introgression of EPAS1 from Denisovans into the ancestors of Tibetans.