RT Journal Article
SR Electronic
T1 Novel quinolone resistance determinant, <em>qepA8</em>, in <em>Shigella flexneri</em> isolated in the United States, 2016
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 726950
DO 10.1101/726950
A1 Hattie E. Webb
A1 Kaitlin A. Tagg
A1 Jessica C. Chen
A1 Justin Kim
A1 Rebecca Lindsey
A1 Louise K. Francois Watkins
A1 Beth E. Karp
A1 Yo Sugawara
A1 Jason P. Folster
YR 2019
UL http://biorxiv.org/content/early/2019/08/06/726950.abstract
AB A qepA8+ Shigella flexneri was cultured from the stool of a traveler returning from India and East Asia. This chromosomally encoded qepA variant, has a six-base insertion, and may have been mobilized as part of a complex IS1-mediated composite transposon including catA1, aadA1, and blaOXA-1. In laboratory E. coli, qepA8 alone only conferred decreased ciprofloxacin susceptibility; however, it may work in combination with additional mechanisms to confer clinical resistance.