RT Journal Article
SR Electronic
T1 Sex differences in maturation and attrition rate of adult born neurons in the hippocampus of rats
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 726398
DO 10.1101/726398
A1 Shunya Yagi
A1 Jared E.J. Splinter
A1 Daria Tai
A1 Sarah Wong
A1 Liisa A.M. Galea
YR 2019
UL http://biorxiv.org/content/early/2019/08/06/726398.abstract
AB Sex differences exist in the regulation of adult neurogenesis in the hippocampus in response to hormones and cognitive training. Here we investigated the trajectory and maturation rate of adult-born neurons in the dentate gyrus (DG) of male and female rats. Sprague-Dawley rats were perfused one, two or three weeks after BrdU injection, marking newly dividing cells. Adult-born neurons (BrdU/NeuN-ir) matured faster in males compared to females. Males had a greater density of neural stem cells (Sox2-ir) in the dorsal, but not in the ventral, DG and had higher levels of cell proliferation (Ki67-ir) than females. Males had a greater reduction in neurogenesis between one and two weeks after mitosis, while females showed similar levels of neurogenesis throughout. The faster maturation and attrition of new neurons suggests greater potential for neurogenesis to respond to external stimuli in males compared to females and emphasizes the importance of studying sex on adult hippocampal neurogenesis.