RT Journal Article
SR Electronic
T1 Post-mortem T<sub>2</sub><sup>*</sup>- weighted MRI imaging of cortical iron reflects severity of Alzheimer’s Disease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 279513
DO 10.1101/279513
A1 Marjolein Bulk
A1 Boyd Kenkhuis
A1 Linda M. van der Graaf
A1 Jelle J. Goeman
A1 Remco Natté
A1 Louise van der Weerd
YR 2018
UL http://biorxiv.org/content/early/2018/03/10/279513.abstract
AB The value of iron-based MRI changes for the diagnosis and staging of Alzheimer’s disease (AD) depends on an association between cortical iron accumulation and AD pathology. Therefore, this study determined the cortical distribution pattern of MRI contrast changes in cortical regions selected based on the known distribution pattern of tau pathology and investigated whether MRI contrast changes reflect the underlying AD pathology in the different lobes.-weighted MRI was performed on post-mortem cortical tissue of controls, late-onset AD, and early-onset AD followed by histology and correlation analyses. Combining ex-vivo high-resolution MRI and histopathology revealed that: LOAD and EOAD have a different distribution pattern of AD pathological hallmarks and MRI contrast changes over the cortex, with EOAD showing more severe MRI changes; (2) per lobe, severity of AD pathological hallmarks correlates with iron accumulation, and hence with MRI. Therefore, iron-sensitive MRI sequences allow detection of the cortical distribution pattern of AD pathology ex-vivo.ADAlzheimer’s diseaseEOADearly-onset ADGMgray matterIRPiron regulating proteinsLOADlate-onset ADMCImild cognitive impairmentPBSphosphate buffered salineQSMquantitative susceptibility mappingWMwhite matter