RT Journal Article
SR Electronic
T1 Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 257311
DO 10.1101/257311
A1 Raymond K. Walters
A1 Mark J. Adams
A1 Amy E. Adkins
A1 Fazil Aliev
A1 Silviu-Alin Bacanu
A1 Anthony Batzler
A1 Sarah Bertelsen
A1 Joanna Biernacka
A1 Tim B. Bigdeli
A1 Li-Shiun Chen
A1 Toni-Kim Clarke
A1 Yi-Ling Chou
A1 Franziska Degenhardt
A1 Anna R. Docherty
A1 Pierre Fontanillas
A1 Jerome Foo
A1 Louis Fox
A1 Josef Frank
A1 Ina Giegling
A1 Scott Gordon
A1 Laura M. Hack
A1 Annette M. Hartmann
A1 Sarah M. Hartz
A1 Stefanie Heilmann-Heimbach
A1 Stefan Herms
A1 Colin Hodgkinson
A1 Per Hoffmann
A1 Jouke-Jan Hottenga
A1 Martin A. Kennedy
A1 Mervi Alanne-Kinnunen
A1 Bettina Konte
A1 Jari Lahti
A1 Marius Lahti-Pulkkinen
A1 Lannie Ligthart
A1 Anu-Maria Loukola
A1 Brion S. Maher
A1 Hamdi Mbarek
A1 Andrew M. McIntosh
A1 Matthew B. McQueen
A1 Yuri Milaneschi
A1 Teemu Palviainen
A1 John F. Pearson
A1 Roseann E. Peterson
A1 Renato Polimanti
A1 Samuli Ripatti
A1 Euijung Ryu
A1 Nancy L. Saccone
A1 Jessica E. Salvatore
A1 Sandra Sanchez-Roige
A1 Melanie Schwandt
A1 Richard Sherva
A1 Fabian Streit
A1 Jana Strohmaier
A1 Nathaniel Thomas
A1 Jen-Chyong Wang
A1 Bradley T. Webb
A1 Robbee Wedow
A1 Leah Wetherill
A1 Amanda G. Wills
A1 23andMe Research Team
A1 Jason D. Boardman
A1 Danfeng Chen
A1 Doo-Sup Choi
A1 William E. Copeland
A1 Robert C. Culverhouse
A1 Norbert Dahmen
A1 Louisa Degenhardt
A1 Benjamin W. Domingue
A1 Sarah L. Elson
A1 Mark Frye
A1 Wolfgang Gäbel
A1 Marcus Ising
A1 Emma C. Johnson
A1 Margaret Keyes
A1 Falk Kiefer
A1 John Kramer
A1 Samuel Kuperman
A1 Susanne Lucae
A1 Michael T. Lynskey
A1 Wolfgang Maier
A1 Karl Mann
A1 Satu Männistö
A1 Jeanette Nance McClintick
A1 Jacquelyn L. Meyers
A1 Bertram Müller-Myhsok
A1 John I. Nurnberger
A1 Aarno Palotie
A1 Ulrich Preuss
A1 Katri Räikkönen
A1 Maureen D. Reynolds
A1 Monika Ridinger
A1 Norbert Scherbaum
A1 Marc Shuckit
A1 Michael Soyka
A1 Jens Treutlein
A1 Stephanie Witt
A1 Norbert Wodarz
A1 Peter Zill
A1 Daniel E. Adkins
A1 Joseph M. Boden
A1 Dorret Boomsma
A1 Laura J Bierut
A1 Sandra A. Brown
A1 Kathleen K. Bucholz
A1 Sven Cichon
A1 E. Jane Costello
A1 Harriet de Wit
A1 Nancy Diazgranados
A1 Danielle M. Dick
A1 Johan G. Eriksson
A1 Lindsay A. Farrer
A1 Tatiana M. Foroud
A1 Nathan A. Gillespie
A1 Alison A. Goate
A1 David Goldman
A1 Richard A. Grucza
A1 Dana B. Hancock
A1 Kathleen Mullan Harris
A1 Andrew C. Heath
A1 Victor Hesselbrock
A1 John K. Hewitt
A1 Christian Hopfer
A1 John Horwood
A1 William Iacono
A1 Eric O. Johnson
A1 Jaakko A. Kaprio
A1 Victor Karpyak
A1 Kenneth S. Kendler
A1 Henry R. Kranzler
A1 Kenneth Krauter
A1 Paul Lichtenstein
A1 Penelope A. Lind
A1 Matt McGue
A1 James MacKillop
A1 Pamela A.F. Madden
A1 Hermine Maes
A1 Patrik Magnusson
A1 Nicholas G. Martin
A1 Sarah E. Medland
A1 Grant W. Montgomery
A1 Elliot C. Nelson
A1 Markus Nöthen
A1 Abraham A. Palmer
A1 Nancy L. Pedersen
A1 Brenda W.J.H. Penninx
A1 Bernice Porjesz
A1 John P. Rice
A1 Marcella Rietschel
A1 Brien P. Riley
A1 Richard Rose
A1 Dan Rujescu
A1 Pei-Hong Shen
A1 Judy Silberg
A1 Michael C. Stallings
A1 Ralph E. Tarter
A1 Michael M. Vanyukov
A1 Scott Vrieze
A1 Tamara L. Wall
A1 John B. Whitfield
A1 Hongyu Zhao
A1 Benjamin M. Neale
A1 Joel Gelernter
A1 Howard J. Edenberg
A1 Arpana Agrawal
YR 2018
UL http://biorxiv.org/content/early/2018/03/10/257311.abstract
AB Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM - IV diagnosed AD. Genome - wide data on 14,904 individuals with AD and 37,944 controls from 28 case / control and family - based studies were meta - analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome - wide significant effects of different ADH1B variants were identified in European (rs1229984; p = 9.8E - 13) and African ancestries (rs2066702; p = 2.2E - 9). Significant genetic correlations were observed with schizophrenia, ADHD, depression, and use of cigarettes and cannabis. There was only modest genetic correlation with alcohol consumption and inconsistent associations with problem drinking. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and non - pathological drinking behaviors.