PT  - JOURNAL ARTICLE
AU  - Zhe Zhao
AU  - Edgar Soria-Gómez
AU  - Marjorie Varilh
AU  - Francisca Julio-Kalajzić
AU  - Astrid Cannich
AU  - Adriana Castiglione
AU  - Léonie Vanhoutte
AU  - Alexia Duveau
AU  - Philippe Zizzari
AU  - Anna Beyeler
AU  - Daniela Cota
AU  - Luigi Bellocchio
AU  - Arnau Busquets-Garcia
AU  - Giovanni Marsicano
TI  - Top-down control of water intake by the endocannabinoid system
AID  - 10.1101/729970
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 729970
4099  - http://biorxiv.org/content/early/2019/08/09/729970.short
4100  - http://biorxiv.org/content/early/2019/08/09/729970.full
AB  - Water intake is regulated by neocortical top-down circuits, but their identity and the cellular mechanisms involved are scantly known. Here, we show that endogenous activation of type-1 cannabinoid receptors (CB1) promotes water intake and that endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala is sufficient to guarantee physiological drinking. These data reveal a new circuit involved in the homeostatic control of water intake.