PT  - JOURNAL ARTICLE
AU  - Christopher J. Black
AU  - Anusha B. Allawala
AU  - Kiernan Bloye
AU  - Kevin N. Vanent
AU  - Muhammad M. Edhi
AU  - Carl Y. Saab
AU  - David A. Borton
TI  - Automated and rapid self-report of nociception in transgenic mice
AID  - 10.1101/732305
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 732305
4099  - http://biorxiv.org/content/early/2019/08/12/732305.1.short
4100  - http://biorxiv.org/content/early/2019/08/12/732305.1.full
AB  - A time-resolved, conscious report of detected nociceptive stimuli in mice offers an opportunity to examine the relationship between higher order neural circuits and pain perception. We have developed a detection behavior in transgenic mice that leverages temporally precise and cell-specific stimulation to elicit self-reports of nociception. Conscious reporting of peripheral nociceptive input may help identify neural mechanisms that generate pain perception.