TY - JOUR T1 - Pseudolesion in the right parafissural liver parenchyma on CT: the base is found in embryology and collagen content JF - bioRxiv DO - 10.1101/732859 SP - 732859 AU - Willemijn M Klein AU - Lianne JP Sonnemans AU - Sabine Franckenberg AU - Barbara Fliss AU - Dominic Gascho AU - Mathias Prokop AU - Wouter H Lamers AU - Jill PJM Hikspoors AU - Michael J Thali AU - Patricia M Flach Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/08/12/732859.abstract N2 - Background Computed tomography (CT) images of livers may show a hypo-attenuated structure alongside the falciform ligament, which can be a focal fatty pseudolesion and can mimic a malignancy. The preferred location is on the right parafissural site, ventral in segment IVa/b. The etiology is not clear, nor is it known how the histology of this location develops. These are evaluated in this study.Methods 40 adult cadavers with autopsy and / or postmortem CT in a university hospital and a forensic center were included. Liver biopsies were taken at the left side of the falciform ligament as control, and at the right side as the possible precursor of a pseudolesion; these were examined for collagen and fat content. Cadavers with steatotic (>5% fat) or fibrotic (>2% collagen) control samples were excluded.Results Significantly more collagen was present in the right parafissural liver parenchyma: median 0.68% (IQR: 0.32 – 1.17%), compared to the left side 0.48% (IQR: 0.21 – 0.75%) (p 0.008), with equal fat content and CT attenuation values. The etiophysiology goes back to the demise of the umbilical venes in the early embryonic and neonatal period.Conclusions The right parafissural area contains more collagen and an equal amount of fat compared to the control left side. This supports the hypothesis of delayed, ‘third’ inflow: the postnatal change in blood supply from umbilical to portal leaves the downstream parafissural area hypoperfused leading to hypoxia which in turn results in collagen accumulation and the persistence of paraumbilical veins of Sappey.Key pointsThe typical location for a parafissural hepatic pseudolesion contains increased collagen.A change in histology is caused by physiological demise of the umbilical venes.The suboptimal blood supply of the right parafissural side leads to hypoxia and collagen deposition.Embryologic knowledge and postmortem histology can help resolve issues in radiology.SDstandard deviationPMCTpostmortem computed tomographyEVGelastic Van GiesonRGBred-green-blueBMIbody mass indexIQRInterquartile range ER -