TY - JOUR T1 - Signaling gradients in surface dynamics as basis for planarian regeneration JF - bioRxiv DO - 10.1101/733246 SP - 733246 AU - Arnd Scheel AU - Angela Stevens AU - Christoph Tenbrock Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/08/13/733246.1.abstract N2 - We introduce and analyze a mathematical model for the regeneration of planarian flatworms. This system of differential equations incorporates dynamics of head and tail cells which express positional control genes that in turn translate into localized signals that guide stem cell differentiation. Orientation and positional information is encoded in the dynamics of a long range wnt-related signaling gradient. We motivate our model in relation to experimental data and demonstrate how it correctly reproduces cut and graft experiments. In particular, our system improves on previous models by preserving polarity in regeneration, over orders of magnitude in body size during cutting experiments and growth phases. Our model relies on tristability in cell density dynamics, between head, trunk, and tail. In addition, key to polarity preservation in regeneration, our system includes sensitivity of cell differentiation to gradients of wnt-related signals relative to the tissue surface. This process is particularly relevant in a small tissue layer close to wounds during their healing, and modeled here in a robust fashion through dynamic boundary conditions. ER -