RT Journal Article SR Electronic T1 Low rate of follow-up colonoscopy after positive results of colorectal cancer screening in a Chinese urban core district JF bioRxiv FD Cold Spring Harbor Laboratory SP 734152 DO 10.1101/734152 A1 Yawen Guo A1 Qingwu Jiang A1 Tetsuya Tanimoto A1 Masahiro Kami A1 Peng Peng A1 Yongpin He A1 Xiaoming Yang A1 Xin Zhang A1 Wenjun Gao A1 Yanming Wang A1 Xiaoting Chu A1 Yunhui Wang A1 Shigeaki Kato A1 Xiaocao Ding YR 2019 UL http://biorxiv.org/content/early/2019/08/13/734152.abstract AB Colorectal cancer (CRC) is one of the most common cancers in China. In 2003, a systematic CRC registry that enables the determination of CRC incidence and mortality and a CRC screening project were introduced in the Jing’an district of Shanghai by the municipal government. This study assessed the registry data to determine the status of CRC and CRC screening rates in the core district of an urban area of China. Data were retrieved from the Official registry information systems of Jing’an district Shanghai Cance. The incidence and mortality of CRC, as well as population-based CRC screening rates, were analysed. Individuals who screened positive for CRC based upon results of a high-risk factor questionnaire (HRFQ) and a faecal immunochemical test (FIT) were selected for follow-up colonoscopy (CSPY). From the registry data collected between 2003 and 2013, the standardized incidence rate was 26.44/105, with a significant gender difference. The CRC standardized mortality rate was 10.08/105. In 2013, 17,866 individuals (21.6%) enrolled for CRC screening among the 82,602 candidate residents. The positive screening rate was 16.28% (2909/17866). Among the 2909 positives, 508 (17.5%) underwent follow-up CSPY. In 41.3% of these individuals (210/508), abnormal lesions were detected. Of these, 8 (1.57%) lesions were diagnosed as CRC, and 142 (28.0%) were identified as precancerous lesions. During the assessment period, both the incidence and mortality of CRC in the Jing’an district were determined in the area of high CRC prevalence in Chin. Nevertheless, the rate of participation in CRC screening was low (21.6%), and the rate of participation in follow-up CSPY for individuals who screened positive was only 17.5%. Improved participation in CRC screening and follow-up CSPY is expected to lower the incidence and mortality of CRC significantly in the rural areas of China. (288)