TY - JOUR T1 - Inferring the landscape of recombination using recurrent neural networks JF - bioRxiv DO - 10.1101/662247 SP - 662247 AU - Jeffrey R. Adrion AU - Jared G. Galloway AU - Andrew D. Kern Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/08/16/662247.abstract N2 - Accurately inferring the genome-wide landscape of recombination rates in natural populations is a central aim in genomics, as patterns of linkage influence everything from genetic mapping to understanding evolutionary history. Here we describe ReLERNN, a deep learning method for accurately estimating a genome-wide recombination landscape using as few as four samples. Rather than use summaries of linkage disequilibrium as its input, ReLERNN considers columns from a genotype alignment, which are then modeled as a sequence across the genome using a recurrent neural network. We demonstrate that ReLERNN improves accuracy and reduces bias relative to existing methods and maintains high accuracy in the face of demographic model misspecification. We apply ReLERNN to natural populations of African Drosophila melanogaster and show that genome-wide recombination landscapes, while largely correlated among populations, exhibit important population-specific differences. Lastly, we connect the inferred patterns of recombination with the frequencies of major inversions segregating in natural Drosophila populations. ER -