PT  - JOURNAL ARTICLE
AU  - Maria Esteban Masferrer
AU  - Bianca A. Silva
AU  - Kensaku Nomoto
AU  - Susana Q. Lima
AU  - Cornelius T. Gross
TI  - Differential encoding of predator fear in the ventromedial hypothalamus and periaqueductal grey
AID  - 10.1101/283820
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 283820
4099  - http://biorxiv.org/content/early/2018/03/17/283820.short
4100  - http://biorxiv.org/content/early/2018/03/17/283820.full
AB  - The ventromedial hypothalamus is a central node of the mammalian predator defense network. Stimulation of this structure in rodents and primates elicits abrupt defensive responses, including flight, freezing, sympathetic activation, and panic, while inhibition reduces defensive responses to predators. The major efferent target of the ventromedial hypothalamus is the dorsal periaqueductal grey, and stimulation of this structure also elicits flight, freezing, and sympathetic activation. However, reversible inhibition experiments suggest that the ventromedial hypothalamus and periaqueductal grey play distinct roles in the control of defensive behavior, with the former proposed to encode an internal state necessary for the motivation of defensive responses, while the latter serves as a motor pattern initiator. Here we used electrophysiological recordings of single units in behaving mice exposed to a rat to investigate the encoding of predator fear in the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey. Distinct correlates of threat intensity and motor responses were found in both structures, suggesting a distributed encoding of sensory and motor features in the medial hypothalamic-brainstem instinctive network.