TY - JOUR T1 - Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain JF - bioRxiv DO - 10.1101/742833 SP - 742833 AU - Milou Straathof AU - Michel R.T. Sinke AU - Theresia J.M. Roelofs AU - Erwin L.A. Blezer AU - R. Angela Sarabdjitsingh AU - Annette van der Toorn AU - Oliver Schmitt AU - Willem M. Otte AU - Rick M. Dijkhuizen Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/08/21/742833.abstract N2 - An improved understanding of the structure-function relationship in the brain is necessary to know to what degree structural connectivity underpins abnormal functional connectivity seen in many disorders. We integrated high-field resting-state fMRI-based functional connectivity with high-resolution macro-scale diffusion-based and meso-scale neuronal tracer-based structural connectivity, to obtain an accurate depiction of the structure-function relationship in the rat brain. Our main goal was to identify to what extent structural and functional connectivity strengths are correlated, macro- and meso-scopically, across the cortex. Correlation analyses revealed a positive correspondence between functional connectivity and macro-scale diffusion-based structural connectivity, but no correspondence between functional connectivity and meso-scale neuronal tracer-based structural connectivity. Locally, strong functional connectivity was found in two well-known resting-state networks: the sensorimotor and default mode network. Strong functional connectivity within these networks coincided with strong short-range intrahemispheric structural connectivity, but with weak heterotopic interhemispheric and long-range intrahemispheric structural connectivity. Our study indicates the importance of combining measures of connectivity at distinct hierarchical levels to accurately determine connectivity across networks in the healthy and diseased brain. Distinct structure-function relationships across the brain can explain the organization of networks and may underlie variations in the impact of structural damage on functional networks and behavior. ER -