RT Journal Article
SR Electronic
T1 Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 739094
DO 10.1101/739094
A1 Lauren E. Salminen
A1 Philipp G. Sämann
A1 Yuanchao Zheng
A1 Emily L. Dennis
A1 Emily K. Clarke-Rubright
A1 Neda Jahanshad
A1 Juan E. Iglesias
A1 Christopher D. Whelan
A1 Steven E. Bruce
A1 Jasmeet P. Hayes
A1 Soraya Seedat
A1 Christopher L. Averill
A1 Lee A. Baugh
A1 Jessica Bomyea
A1 Joanna Bright
A1 Chanellé J. Buckle
A1 Kyle Choi
A1 Nicholas D. Davenport
A1 Richard J. Davidson
A1 Maria Densmore
A1 Seth G. Disner
A1 Stefan du Plessis
A1 Jeremy A. Elman
A1 Negar Fani
A1 Gina L. Forster
A1 Carol E. Franz
A1 Jessie L. Frijling
A1 Atilla Gonenc
A1 Staci A. Gruber
A1 Daniel W. Grupe
A1 Jeffrey P. Guenette
A1 Courtney C. Haswell
A1 David Hofmann
A1 Michael Hollifield
A1 Babok Hosseini
A1 Anna R. Hudson
A1 Jonathan Ipser
A1 Tanja Jovanovic
A1 Amy Kennedy-Krage
A1 Mitzy Kennis
A1 Anthony King
A1 Philipp Kinzel
A1 Saskia B. J. Koch
A1 Inga Koerte
A1 Sheri M. Koopowitz
A1 Mayuresh S. Korgaonkar
A1 William S. Kremen
A1 John Krystal
A1 Lauren A. M. Lebois
A1 Ifat Levy
A1 Michael J. Lyons
A1 Vincent A. Magnotta
A1 Antje Manthey
A1 Soichiro Nakahara
A1 Laura Nawijn
A1 Richard W. J. Neufeld
A1 Jack B. Nitschke
A1 Daniel C. M. O’Doherty
A1 Robert H. Paul
A1 Matthew Peverill
A1 Faisal M. Rashid
A1 Kerry J. Ressler
A1 Annerine Roos
A1 Christian Schmahl
A1 Margaret A. Sheridan
A1 Anika Sierk
A1 Alan N. Simmons
A1 Jeffrey S. Simons
A1 Raluca M. Simons
A1 Murray B. Stein
A1 Jennifer S. Stevens
A1 Benjamin Suarez-Jimenez
A1 Jean Théberge
A1 Kathleen Thomaes
A1 Sophia I. Thomopoulos
A1 Leigh L. van den Heuvel
A1 Steven J. A. van der Werff
A1 Theo G. M. van Erp
A1 Sanne J. H. van Rooij
A1 Mirjam van Zuiden
A1 Tim Varkevisser
A1 Robert R. J. M. Vermeiren
A1 Tor D. Wager
A1 Henrik Walter
A1 Xin Wang
A1 Sherry Winternitz
A1 Jonathan D. Wolff
A1 Kristen Wrocklage
A1 Xi Zhu
A1 Christopher R. K. Ching
A1 Tiril P. Gurholt
A1 Unn K. Haukvik
A1 Ingrid Agartz
A1 Chadi G. Abdallah
A1 Richard Bryant
A1 Judith K. Daniels
A1 Michael DeBellis
A1 Kelene A. Fercho
A1 Elbert Geuze
A1 Ilan Harpaz-Rotem
A1 Julia I. Herzog
A1 Milissa L. Kaufman
A1 Jim Lagopoulos
A1 Ruth A. Lanius
A1 Katie A. McLaughlin
A1 Sven C. Mueller
A1 Yuval Neria
A1 Miranda Olff
A1 K. Luan Phan
A1 Martha E. Shenton
A1 Scott R. Sponheim
A1 Dan J. Stein
A1 Thomas Straube
A1 Nic J. A. van der Wee
A1 Dick J. Veltman
A1 Paul M. Thompson
A1 Rajendra A. Morey
A1 Mark W. Logue
A1 for the ENIGMA-PGC-PTSD Working Group
YR 2019
UL http://biorxiv.org/content/early/2019/08/21/739094.abstract
AB Background PTSD and depression commonly co-occur and have been associated with smaller hippocampal volumes compared to healthy and trauma-exposed controls. However, the hippocampus is heterogeneous, with subregions that may be uniquely affected in individuals with PTSD and depression.Methods We used random effects regressions and a harmonized neuroimaging protocol based on FreeSurfer (v6.0) to identify sub-structural hippocampal markers of current PTSD (C-PTSD), depression, and the interaction of these conditions across 31 cohorts worldwide (N=3,115; Mage=38.9±13.9 years). Secondary analyses tested these associations by sex and after modeling the simultaneous effects of remitted PTSD, childhood trauma, mild traumatic brain injury, and alcohol use disorder.Results A significant negative main effect of depression (n=800, vs. no depression, n=1456) was observed in the hippocampal tail (ß=−0.13) and CA1 (ß=−0.09) after adjusting for covariates and multiple testing (adjusted p’s (q)=0.028). A main effect of C-PTSD (n=1042 vs. control, n=1359) was not significant, but an interaction between C-PTSD and depression was significant in the CA1 (ß=−0.24, q=0.044). Pairwise comparisons revealed significantly smaller CA1 volumes in individuals with C-PTSD+Depression than controls (ß=−0.12, q=0.012), C-PTSD-only (ß=−0.17, q=0.001), and Depression-only (ß=−0.18, q=0.023). Follow-up analyses revealed sex effects in the hippocampal tail of depressed females, and an interaction effect of C-PTSD and depression in the fimbria of males.Conclusions Collectively our results suggest that depression is a stronger predictor of hippocampal volumetry than PTSD, particularly in the CA1, and provide compelling evidence of more pronounced hippocampal phenotypes in comorbid PTSD and depression compared to either condition alone.