PT  - JOURNAL ARTICLE
AU  - Yizhou Zhu
AU  - Yousin Suh
TI  - Tri-4C: efficient identification of cis-regulatory loops at hundred base pair resolution
AID  - 10.1101/743005
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 743005
4099  - http://biorxiv.org/content/early/2019/08/22/743005.short
4100  - http://biorxiv.org/content/early/2019/08/22/743005.full
AB  - Here we present Tri-4C, a targeted chromatin conformation capture method for ultrafine mapping of chromatin interactions. Tri-4C quantitatively reveals cis-regulatory loops with unprecedented resolution, identifying functional enhancer loops devoid of typical epigenomic marks and uncovering allele-specific loop alterations in enhancer interaction networks underlying dynamic gene control. The Tri-4C approach is applicable to general 3C-derived methods for the study of single-allele enhancer loop networks.