RT Journal Article
SR Electronic
T1 CMU Array: A 3D Nano-Printed, Customizable Ultra-High-Density Microelectrode Array Platform
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 742346
DO 10.1101/742346
A1 Mohammad Sadeq Saleh
A1 Sandra M. Ritchie
A1 Mark A. Nicholas
A1 Rriddhiman Bezbaruah
A1 Jay W. Reddy
A1 Maysamreza Chamanzar
A1 Eric A. Yttri
A1 Rahul P. Panat
YR 2019
UL http://biorxiv.org/content/early/2019/08/23/742346.abstract
AB Microelectrode arrays (MEAs) provide the means to record electrophysiological activity fundamental to both basic and clinical neuroscience (e.g. brain-computer interfaces). Despite recent advances, current MEAs have significant limitations – including low recording density, fragility, expense, and the inability to optimize the probe to individualized study or patient needs. Here we address the technological limitations through the utilization of the newest developments in 3D nanoparticle printing.1 Our ‘CMU Arrays’ possess previously impossible electrode densities (> 6000 channels/cm2) with tip diameters as small as 10 μm. Most importantly, the probes are entirely customizable owing to the adaptive manufacturing process. Any combination of individual shank lengths, impedances, and layouts are possible. This is achieved in part via our new multi-layer, multi material, custom 3D-printed circuit boards, a fabrication advancement in itself. This device design enables new experimental avenues of targeted, large-scale recording of electrical signals from a variety of biological tissues.