RT Journal Article
SR Electronic
T1 Why not record from every channel with a CMOS scanning probe?
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 275818
DO 10.1101/275818
A1 George Dimitriadis
A1 Joana P. Neto
A1 Arno Aarts
A1 Andrei Alexandru
A1 Marco Ballini
A1 Francesco Battaglia
A1 Lorenza Calcaterra
A1 Francois David
A1 Richárd Fiáth
A1 João Frazão
A1 Jesse P Geerts
A1 Luc J. Gentet
A1 Nick Van Helleputte
A1 Tobias Holzhammer
A1 Chris van Hoof
A1 Domonkos Horváth
A1 Gonçalo Lopes
A1 Carolina M. Lopez
A1 Eric Maris
A1 Andre Marques-Smith
A1 Gergely Márton
A1 Bruce L. McNaughton
A1 Domokos Meszéna
A1 Srinjoy Mitra
A1 Silke Musa
A1 Hercules Neves
A1 Joana Nogueira
A1 Guy A. Orban
A1 Frederick Pothof
A1 Jan Putzeys
A1 Bogdan Raducanu
A1 Patrick Ruther
A1 Tim Schroeder
A1 Wolf Singer
A1 Paul Tiesinga
A1 Istvan Ulbert
A1 Shiwei Wang
A1 Marleen Welkenhuysen
A1 Adam R. Kampff
YR 2018
UL http://biorxiv.org/content/early/2018/03/21/275818.abstract
AB Neural recording devices normally require one output connection for each electrode. This constrains the number of electrodes that can be accommodated by the thin shafts of implantable probes. Sharing a single output connection between multiple electrodes relaxes this constraint and permits designs of ultra-high density neural probes.Here we report the design and in vivo validation of such a device, a complementary metal-oxide-semiconductor (CMOS) scanning probe with 1344 electrodes and 12 reference electrodes along an 8.1 mm × 100 μm × 50 μm shaft; the outcome of the European research project NeuroSeeker. This technology presented new challenges for data management and visualization, and we also report new methods addressing these challenges developed within NeuroSeeker.Scanning CMOS technology allows the fabrication of much smaller, denser electrode arrays. To help design electrode configurations for future probes, several recordings from many different brain regions were made with an ultra-dense passive probe fabricated using CMOS process. All datasets are available online.