PT  - JOURNAL ARTICLE
AU  - Hal Tily
AU  - Ally Perlina
AU  - Eric Patridge
AU  - Stephanie Gline
AU  - Matvey Genkin
AU  - Vishakh Gopu
AU  - Haely Lindau
AU  - Alisson Sjue
AU  - Iordan Slavov
AU  - Niels Klitgord
AU  - Momchilo Vuyisich
AU  - Helen Messier
AU  - Guruduth Banavar
TI  - Gut microbiome activity contributes to individual variation in glycemic response in adults
AID  - 10.1101/641019
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 641019
4099  - http://biorxiv.org/content/early/2019/08/24/641019.short
4100  - http://biorxiv.org/content/early/2019/08/24/641019.full
AB  - Limiting post-meal glycemic response is an important factor in reducing the risk of chronic metabolic diseases, and contributes to significant health benefits in people with elevated levels of blood sugar. In this study, we collected gut microbiome activity (i.e., metatranscriptomic) data and measured the glycemic responses of 550 adults who consumed more than 30,000 meals from omnivore or vegetarian/gluten-free diets. We demonstrate that gut microbiome activity makes a statistically significant contribution to individual variation in glycemic response, in addition to anthropometric factors and the nutritional composition of foods. We describe predictive models (multilevel mixed-effects regression and gradient boosting machine) of variation in glycemic response among individuals ingesting the same foods. We introduce functional features aggregated from microbial activity data as candidates for association with mechanisms of glycemic control. In summary, we demonstrate for the first time that metatranscriptomic activity of the gut microbiome is correlated with glycemic response among adults.