RT Journal Article SR Electronic T1 Urbanization shapes the demographic history of a city-dwelling native rodent JF bioRxiv FD Cold Spring Harbor Laboratory SP 032979 DO 10.1101/032979 A1 Stephen E. Harris A1 Alexander T. Xue A1 Diego Alvarado-Serrano A1 Joel T. Boehm A1 Tyler Joseph A1 Michael J. Hickerson A1 Jason Munshi-South YR 2015 UL http://biorxiv.org/content/early/2015/11/26/032979.abstract AB How urbanization shapes population genomic diversity and evolution of urban wildlife is largely unexplored. We investigated the impact of urbanization on white-footed mice, Peromyscus leucopus, in the New York City metropolitan area using coalescent-based simulations to infer demographic history from the site frequency spectrum. We assigned individuals to evolutionary clusters and then inferred recent divergence times, population size changes, and migration using genome-wide SNPs genotyped in 23 populations sampled along an urban-to-rural gradient. Both prehistorical climatic events and recent urbanization impacted these populations. Our modeling indicates that post-glacial sea level rise led to isolation of mainland and Long Island populations. These models also indicate that several urban parks represent recently-isolated P. leucopus populations, and the estimated divergence times for these populations are consistent with the history of urbanization in New York City.