PT  - JOURNAL ARTICLE
AU  - Matthias I Gröschel
AU  - Conor J Meehan
AU  - Ivan Barilar
AU  - Margo Diricks
AU  - Aitor Gonzaga
AU  - Matthias Steglich
AU  - Oscar Conchillo-Solé
AU  - Isabell-Christin Scherer
AU  - Uwe Mamat
AU  - Christian F. Luz
AU  - Katrien De Bruyne
AU  - Christian Utpatel
AU  - Daniel Yero
AU  - Isidre Gibert
AU  - Xavier Daura
AU  - Stefanie Kampmeier
AU  - Nurdyana Abdul Rahman
AU  - Michael Kresken
AU  - Tjip S van der Werf
AU  - Ifey Alio
AU  - Wolfgang R. Streit
AU  - Kai Zhou
AU  - Thomas Schwartz
AU  - John W A Rossen
AU  - Maha R Farhat
AU  - Ulrich E Schaible
AU  - Ulrich Nübel
AU  - Jan Rupp
AU  - Joerg Steinmann
AU  - Stefan Niemann
AU  - Thomas A Kohl
TI  - The global phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist <em>Stenotrophomonas maltophilia</em>
AID  - 10.1101/748954
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 748954
4099  - http://biorxiv.org/content/early/2019/08/28/748954.short
4100  - http://biorxiv.org/content/early/2019/08/28/748954.full
AB  - Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analysed an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harboured strains of all degrees of human virulence. Lineage Sm6 comprised the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identified potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.One Sentence Summary The S. maltophilia complex comprises genetically diverse, globally distributed lineages with evidence for intra-hospital transmission.