RT Journal Article
SR Electronic
T1 Autoreactive T cells preferentially drive differentiation of non-responsive memory B cells at the expense of germinal center maintenance
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 287789
DO 10.1101/287789
A1 Jain, Rajiv W
A1 Parham, Kate A
A1 Tesfagiorgis, Yodit
A1 Craig, Heather C
A1 Romanchik, Emiliano
A1 Kerfoot, Steven M
YR 2018
UL http://biorxiv.org/content/early/2018/03/23/287789.abstract
AB B cell fate decisions within a germinal center (GC) are critical to determining the outcome of the immune response to a given antigen. Here, we characterize GC kinetics and B cell fate choices in a response to the autoantigen myelin oligodendrocyte glycoprotein (MOG), and compare them the response to a standard model foreign antigen (NP-haptenated ovalbumin, NPOVA). Both antigens generated productive primary responses, as evidenced by GC development, circulating antigen-specific antibodies, and differentiation of memory B cells. However, in the MOG response the status of the cognate T cell partner drove preferential B cell differentiation to a memory phenotype at the expense of GC maintenance, resulting in a truncated GC. Reduced plasma cell differentiation was largely independent of T cell influence. Interestingly, memory B cells formed in the MOG GC were unresponsive to secondary challenge and this could not be overcome with T cell help.