%0 Journal Article %A Mateus R. Amorim %A Júnia L. de Deus %A Camila A. Pereira %A Luiz E. V. da Silva %A Gabriela S. Borges %A Nathanne S. Ferreira %A Marcelo E. Batalhão %A José Antunes-Rodrigues %A Evelin C. Cárnio %A Rita C. Tostes %A Luiz G. S. Branco %T Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation %D 2019 %R 10.1101/748608 %J bioRxiv %P 748608 %X Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles. We hypothesized that baroreceptor denervation affects lipopolysaccharide (LPS)-induced systemic inflammation (SI) and hemodynamic collapse in conscious rats, and that these parameters are interconnected. We combine: a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like dose b) analysis of the cardiovascular complexity, c) evaluation of vascular function in mesenteric resistance vessels, and d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that sino-aortic afferents are key to alleviate LPS-induced cardiovascular collapse, affecting the autonomic cardiovascular control, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse seem not to be interconnected. %U https://www.biorxiv.org/content/biorxiv/early/2019/08/29/748608.full.pdf