RT Journal Article
SR Electronic
T1 LINbase: A Web service for genome-based identification of microbes as members of crowdsourced taxa
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 752212
DO 10.1101/752212
A1 Long Tian
A1 Chengjie Huang
A1 Lenwood S. Heath
A1 Boris A. Vinatzer
YR 2019
UL http://biorxiv.org/content/early/2019/08/31/752212.abstract
AB The development of next generation and third generation DNA sequencing technologies in combination with new efficient algorithms allows scientists to economically, quickly, and precisely identify microbes at all taxonomic levels and even attribute pathogen isolates to specific disease outbreaks. However, current taxonomic practice has not kept up with the sequencing revolution and continues to rely on cumbersome journal publications to describe new species. Here we introduce a Web service that allows any user to genomically circumscribe any monophyletic group of bacteria as a taxon and associate with each taxon a name and short description. Any other user can immediately identify their unknown microbe as a member of any of these crowdsourced taxa using gene or genome sequences. The Web service is called LINbase. It leverages the previously described concept of Life Identification Numbers (LINs), which are codes assigned to individual organisms based on genome similarity. Most genomes currently in LINbase were imported from GenBank, but users have the option to upload their own genome sequences as well. Importantly, LINbase allows users to share the precise identity of their sequenced genomes without sharing the actual genome sequences, making not yet published or private genome sequences discoverable by the scientific community stimulating collaboration between academia and industry. LINbase is available at http://www.LINbase.org.