PT  - JOURNAL ARTICLE
AU  - Mirna Marinić
AU  - Vincent J. Lynch
TI  - Derivation of endometrial gland organoids from term post-partum placenta
AID  - 10.1101/753780
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 753780
4099  - http://biorxiv.org/content/early/2019/08/31/753780.short
4100  - http://biorxiv.org/content/early/2019/08/31/753780.full
AB  - A major limitation of recently developed methods for the generation of endometrial gland organoids is their reliance on decidua isolated from endometrial biopsies or elective termination of pregnancies. Here we report the successful establishment of endometrial gland organoids from decidua isolated from term placental membranes, as well as the identification of potential survival factors for the co-culture of gland organoids and endometrial stromal fibroblasts. These modifications facilitate the generation of patient-specific endometrial gland organoids with known pregnancy outcomes, such as term vs. preterm birth.