RT Journal Article
SR Electronic
T1 Undulating changes in human plasma proteome across lifespan are linked to disease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 751115
DO 10.1101/751115
A1 Benoit Lehallier
A1 David Gate
A1 Nicholas Schaum
A1 Tibor Nanasi
A1 Song Eun Lee
A1 Hanadie Yousef
A1 Patricia Moran Losada
A1 Daniela Berdnik
A1 Andreas Keller
A1 Joe Verghese
A1 Sanish Sathyan
A1 Claudio Franceschi
A1 Sofiya Milman
A1 Nir Barzilai
A1 Tony Wyss-Coray
YR 2019
UL http://biorxiv.org/content/early/2019/09/01/751115.abstract
AB Aging is the predominant risk factor for numerous chronic diseases that limit healthspan. Mechanisms of aging are thus increasingly recognized as therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues, pointing to the intriguing possibility that age-related molecular changes in blood can provide novel insight into disease biology. We measured 2,925 plasma proteins from 4,331 young adults to nonagenarians and developed a novel bioinformatics approach which uncovered profound non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh, and eighth decades of life reflected distinct biological pathways, and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways of aging and disease and offers potential pathways for aging interventions.