TY - JOUR T1 - Distinct polysaccharide growth profiles of human intestinal <em>Prevotella copri</em> isolates JF - bioRxiv DO - 10.1101/750802 SP - 750802 AU - Hannah Fehlner-Peach AU - Cara Magnabosco AU - Varsha Raghavan AU - Jose U. Scher AU - Adrian Tett AU - Laura M. Cox AU - Claire Gottsegen AU - Aaron Watters AU - John D. Wiltshire-Gordon AU - Nicola Segata AU - Richard Bonneau AU - Dan R. Littman Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/09/03/750802.abstract N2 - The gut-dwelling Prevotella copri, the most prevalent Prevotella species in human gut, have been associated with diet as well as disease, but our understanding of their diversity and functional roles remains rudimentary, as studies have been limited to 16S and metagenomic surveys and experiments using a single type strain. Here, we describe the genomic diversity of 83 P. copri isolates from 11 donors. We demonstrate that genomically distinct isolates, which can be categorized into different P. copri complex clades, utilize defined sets of plant polysaccharides that can be predicted in part from their genomes and from metagenomic data. This study thus reveals both genomic and functional differences in polysaccharide utilization between several novel human intestinal P. copri strains. ER -