TY - JOUR T1 - Modeling brain dynamics after tumor resection using The Virtual Brain JF - bioRxiv DO - 10.1101/752931 SP - 752931 AU - Hannelore Aerts AU - Michael Schirner AU - Thijs Dhollander AU - Ben Jeurissen AU - Eric Achten AU - Dirk Van Roost AU - Petra Ritter AU - Daniele Marinazzo Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/09/05/752931.abstract N2 - Brain tumor patients scheduled for tumor resection often face significant uncertainty, as the outcome of neurosurgery is difficult to predict at the individual patient level. Recently, computational modeling of brain activity using so-called brain network models has been introduced as a promising tool for this purpose. However, brain network models first have to be validated, before they can be used to predict brain dynamics. In prior work, we optimized individual brain network model parameters to maximize the fit with empirical brain activity. In this study, we extend this line of research by examining the stability of fitted parameters before and after tumor resection, and compare it with baseline parameter variability using data from healthy control subjects. Based on these findings, we perform the first “virtual neurosurgery” analyses to evaluate the potential of brain network modeling in predicting brain dynamics after tumor resection.We find that brain network model parameters are relatively stable over time in brain tumor patients who underwent tumor resection, compared with baseline variability in healthy control subjects. In addition, we identify several robust associations between individually optimized model parameters, structural network topology and cognitive performance from pre-to post-operative assessment. Concerning the virtual neurosurgery analyses, we obtain promising results in some patients, whereas the predictive accuracy of the currently applied model is poor in others. These findings reveal interesting avenues for future research, as well as important limitations that warrant further investigation. ER -