RT Journal Article
SR Electronic
T1 Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 292029
DO 10.1101/292029
A1 Andrew Dhawan
A1 Adrian L. Harris
A1 Francesca M. Buffa
A1 Jacob G. Scott
YR 2018
UL http://biorxiv.org/content/early/2018/03/31/292029.abstract
AB Oscillations are crucial to the sustenance of living organisms, across a wide variety of biological processes. In eukaryotes, oscillatory dynamics are thought to arise from inter-actions at the protein and RNA levels; however, the role of non-coding RNA in regulating these dynamics remains understudied. In this work, using a mathematical model, we show how non-coding RNA acting as miRNA sponges in a conserved miRNA - transcription factor feedback motif, can give rise to oscillatory behaviour. Control of these non-coding RNA can dynamically create oscillations or stability, and we show how this behaviour predisposes to oscillations in the stochastic limit. These results point towards novel hypotheses for the roles of different species of miRNA sponges, and help to provide a paradigm for functional differences between the many distinct RNA species thought to act as miRNA sponges in nature.