PT  - JOURNAL ARTICLE
AU  - J. Zimmermann
AU  - J. Griffiths
AU  - M. Schirner
AU  - P. Ritter
AU  - A.R. McIntosh
TI  - Subject-specificity of the correlation between large-scale structural and functional connectivity
AID  - 10.1101/277590
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 277590
4099  - http://biorxiv.org/content/early/2018/04/03/277590.short
4100  - http://biorxiv.org/content/early/2018/04/03/277590.full
AB  - Structural connectivity (SC), the physical pathways connecting regions in the brain, and functional connectivity (FC), the temporal co-activations, are known to be tightly linked. However, the nature of this relationship is still not understood. In the present study, we examined this relation more closely in six separate human neuroimaging datasets with different acquisition and preprocessing methods. We show that using simple linear associations, the relation between an individual’s SC and FC is not subject-specific for five of the datasets. Subject-specificity of SC-FC fit is achieved only for one of the six datasets, the multi-modal Glasser HCP parcellated dataset. We show that subject-specificity of SC-FC correspondence is limited across datasets due to relatively small variability between subjects in SC compared to the larger variability in FC.