RT Journal Article
SR Electronic
T1 Subject-specificity of the correlation between large-scale structural and functional connectivity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 277590
DO 10.1101/277590
A1 J. Zimmermann
A1 J. Griffiths
A1 M. Schirner
A1 P. Ritter
A1 A.R. McIntosh
YR 2018
UL http://biorxiv.org/content/early/2018/04/03/277590.abstract
AB Structural connectivity (SC), the physical pathways connecting regions in the brain, and functional connectivity (FC), the temporal co-activations, are known to be tightly linked. However, the nature of this relationship is still not understood. In the present study, we examined this relation more closely in six separate human neuroimaging datasets with different acquisition and preprocessing methods. We show that using simple linear associations, the relation between an individual’s SC and FC is not subject-specific for five of the datasets. Subject-specificity of SC-FC fit is achieved only for one of the six datasets, the multi-modal Glasser HCP parcellated dataset. We show that subject-specificity of SC-FC correspondence is limited across datasets due to relatively small variability between subjects in SC compared to the larger variability in FC.